Baseline factors associated with early and late death in intracerebral haemorrhage survivors
Autor: | Banerjee, G, Ambler, G, Wilson, D, Hostettler, IC, Shakeshaft, C, Lunawat, S, Cohen, H, Yousry, T, Salman, R Al-Shahi, Lip, GYH, Houlden, H, Muir, KW, Brown, MM, Jager, HR, Werring, DJ, Collaborators, CROMIS-2 |
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Rok vydání: | 2020 |
Předmět: |
Male
Change over time medicine.medical_specialty Cohort Studies 03 medical and health sciences 0302 clinical medicine Risk Factors Modified Rankin Scale Internal medicine Humans Medicine Glasgow Coma Scale Anticoagulant use Survivors 030212 general & internal medicine Aged Cerebral Hemorrhage Aged 80 and over business.industry Hazard ratio intracerebral haemorrhage Middle Aged Prognosis mortality Confidence interval Stroke Neurology Cohort Original Article Female Observational study prognosis Neurology (clinical) business 030217 neurology & neurosurgery |
Zdroj: | EUROPEAN JOURNAL OF NEUROLOGY Banerjee, G, Ambler, G, Wilson, D, Hostettler, I C, Shakeshaft, C, Lunawat, S, Cohen, H, Yousry, T, Al-shahi Salman, R, Lip, G Y H, Houlden, H, Muir, K W, Brown, M M, Jäger, H R & Werring, D J 2020, ' Baseline factors associated with early and late death in intracerebral haemorrhage survivors ', European Journal of Neurology . https://doi.org/10.1111/ene.14238 Banerjee, G, Ambler, G, Wilson, D, Hostettler, I C, Shakeshaft, C, Lunawat, S, Cohen, H, Yousry, T, Al-Shahi Salman, R, Lip, G Y H, Houlden, H, Muir, K W, Brown, M M, Jäger, H R, Werring, D J & CROMIS-2 collaborators 2020, ' Baseline factors associated with early and late death in intracerebral haemorrhage survivors ', European Journal of Neurology, vol. 27, no. 7, pp. 1257-1263 . https://doi.org/10.1111/ene.14238 European Journal of Neurology |
ISSN: | 1468-1331 1351-5101 |
Popis: | Background and purpose: \ud \ud The aim of this study was to determine whether early and late death are associated with different baseline factors in intracerebral haemorrhage (ICH) survivors.\ud \ud Methods: \ud \ud This was a secondary analysis of the multicentre prospective observational CROMIS‐2 ICH study. Death was defined as ‘early’ if occurring within 6 months of study entry and ‘late’ if occurring after this time point.\ud \ud Results: \ud \ud In our cohort (n = 1094), there were 306 deaths (per 100 patient‐years: absolute event rate, 11.7; 95% confidence intervals, 10.5–13.1); 156 were ‘early’ and 150 ‘late’. In multivariable analyses, early death was independently associated with age [per year increase; hazard ratio (HR), 1.05, P = 0.003], history of hypertension (HR, 1.89, P = 0.038), pre‐event modified Rankin scale score (per point increase; HR, 1.41, P < 0.0001), admission National Institutes of Health Stroke Scale score (per point increase; HR, 1.11, P < 0.0001) and haemorrhage volume >60 mL (HR, 4.08, P < 0.0001). Late death showed independent associations with age (per year increase; HR, 1.04, P = 0.003), pre‐event modified Rankin scale score (per point increase; HR, 1.42, P = 0.001), prior anticoagulant use (HR, 2.13, P = 0.028) and the presence of intraventricular extension (HR, 1.73, P = 0.033) in multivariable analyses. In further analyses where time was treated as continuous (rather than dichotomized), the HR of previous cerebral ischaemic events increased with time, whereas HRs for Glasgow Coma Scale score, National Institutes of Health Stroke Scale score and ICH volume decreased over time.\ud \ud Conclusions: \ud \ud We provide new evidence that not all baseline factors associated with early mortality after ICH are associated with mortality after 6 months and that the effects of baseline variables change over time. Our findings could help design better prognostic scores for later death after ICH. |
Databáze: | OpenAIRE |
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