Bioadhesive Polymeric Films Based on Red Onion Skins Extract for Wound Treatment: An Innovative and Eco-Friendly Formulation
| Autor: | Roberta Ortenzi, Claudio Baiocchi, Maria Cristina Tiralti, Maura Marinozzi, Maria Rachele Ceccarini, Elena Orecchini, Stefania Scuota, Luana Perioli, Ciriana Orabona, Michela Chielli, Paola Calarco, Tommaso Beccari, Cinzia Pagano, Maurizio Ricci |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Swine
030309 nutrition & dietetics Bioadhesive Anti-Inflammatory Agents Pharmaceutical Science Waste material onion skins extract hydrogel polymeric films anti-inflammatory antibacterial Article Analytical Chemistry lcsh:QD241-441 Mice 03 medical and health sciences Human health lcsh:Organic chemistry Onions Drug Discovery Animals Food science Physical and Theoretical Chemistry Wound treatment Skin 030304 developmental biology Wound Healing 0303 health sciences Plant Extracts Chemistry Organic Chemistry Membranes Artificial Biocompatible material Environmentally friendly Anti-Bacterial Agents Solvent RAW 264.7 Cells Chemistry (miscellaneous) Molecular Medicine Tissue Adhesives Extraction methods |
| Zdroj: | Molecules, Vol 25, Iss 2, p 318 (2020) Molecules Volume 25 Issue 2 |
| Popis: | The onion non-edible outside layers represent a widely available waste material deriving from its processing and consumption. As onion is a vegetable showing many beneficial properties for human health, a study aiming to evaluate the use of extract deriving from the non-edible outside layers was planned. An eco-friendly extraction method was optimized using a hydroalcoholic solution as solvent. The obtained extract was deeply characterized by in vitro methods and then formulated in autoadhesive, biocompatible and pain-free hydrogel polymeric films. The extract, very soluble in water, showed antioxidant, radical scavenging, antibacterial and anti-inflammatory activities, suggesting a potential dermal application for wounds treatment. In vitro studies showed a sustained release of the extract from the hydrogel polymeric film suitable to reach concentrations necessary for both antibacterial and anti-inflammatory activities. Test performed on human keratinocytes showed that the formulation is safe suggesting that the projected formulation could be a valuable tool for wound treatment. |
| Databáze: | OpenAIRE |
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