Response to treatment and long-term outcomes in kidney transplant recipients with acute T cell–mediated rejection
| Autor: | Jean-Paul Duong Van Huyen, Christophe Legendre, Alexandre Loupy, Olivier Aubert, Denis Glotz, Yassine Bouatou, Daniele Pievani, Marion Rabant, Denis Viglietti, Carmen Lefaucheur, Jean-Luc Taupin, Kevin Louis |
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| Rok vydání: | 2019 |
| Předmět: |
Graft Rejection
Male medicine.medical_specialty T-Lymphocytes T cell Renal function 030230 surgery Kidney Function Tests Gastroenterology 03 medical and health sciences 0302 clinical medicine Adrenal Cortex Hormones HLA Antigens Isoantibodies Risk Factors Internal medicine medicine Humans Immunology and Allergy Pharmacology (medical) Prospective Studies Prospective cohort study Inflammation Transplantation Kidney Proteinuria business.industry Incidence (epidemiology) Graft Survival Middle Aged Allografts Prognosis Kidney Transplantation Response to treatment medicine.anatomical_structure Female medicine.symptom business Follow-Up Studies Glomerular Filtration Rate |
| Zdroj: | American Journal of Transplantation. 19:1972-1988 |
| ISSN: | 1600-6135 |
| DOI: | 10.1111/ajt.15299 |
| Popis: | The recent recognition of complex and chronic phenotypes of T cell-mediated rejection (TCMR) has fostered the need to better evaluate the response of acute TCMR-a condition previously considered to lack relevant consequences for allograft survival-to the standard of care. In a prospective cohort of kidney recipients (n = 256) with biopsy-proven acute TCMR receiving corticosteroids, we investigated clinical, histological, and immunological phenotypes at the time of acute TCMR diagnosis and 3 months posttreatment. Independent posttreatment determinants of allograft loss included the glomerular filtration rate (GFR) (HR = 0.94; 95% CI = 0.92-0.96; P |
| Databáze: | OpenAIRE |
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