N-Acyl taurines trigger insulin secretion by increasing calcium flux in pancreatic β-cells
| Autor: | Mary C. Hunt, Helena Aro, Sepide Derakhshan, Katarina Vielfort, Dominik P. Waluk |
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| Rok vydání: | 2013 |
| Předmět: |
Cytoplasm
medicine.medical_specialty Taurine medicine.medical_treatment Biophysics TRPV Cation Channels chemistry.chemical_element Oleic Acids Arachidonic Acids Calcium Biochemistry Calcium in biology Cell Line chemistry.chemical_compound Cricetinae Insulin-Secreting Cells Internal medicine Insulin receptor substrate Insulin Secretion Calcium flux medicine Animals Insulin Molecular Biology Calcium metabolism biology Cell Biology Rats Insulin receptor Endocrinology chemistry biology.protein lipids (amino acids peptides and proteins) |
| Zdroj: | Biochemical and Biophysical Research Communications. 430:54-59 |
| ISSN: | 0006-291X |
| Popis: | Pancreatic β-cells secrete insulin in response to various stimuli to control blood glucose levels. This insulin release is the result of a complex interplay between signaling, membrane potential and intracellular calcium levels. Various nutritional and hormonal factors are involved in regulating this process. N-Acyl taurines are a group of fatty acids which are amidated (or conjugated) to taurine and little is known about their physiological functions. In this study, treatment of pancreatic β-cell lines (HIT-T15) and rat islet cell lines (INS-1) with N-acyl taurines (N-arachidonoyl taurine and N-oleoyl taurine), induced a high frequency of calcium oscillations in these cells. Treatment with N-arachidonoyl taurine and N-oleoyl taurine also resulted in a significant increase in insulin secretion from pancreatic β-cell lines as determined by insulin release assay and immunofluorescence (p |
| Databáze: | OpenAIRE |
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