Ovarian Steroids: The Good, the Bad, and the Signals that Raise Them
| Autor: | Michelle Jamnongjit, Stephen R. Hammes |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Infertility
medicine.medical_specialty media_common.quotation_subject Ovary Biology Article Internal medicine medicine Animals Molecular Biology Ovulation media_common Steroidogenic acute regulatory protein Cell Biology Oocyte medicine.disease Hormones medicine.anatomical_structure Endocrinology Female Steroids Signal transduction Luteinizing hormone Signal Transduction Developmental Biology Hormone |
| Zdroj: | Cell Cycle. 5:1178-1183 |
| ISSN: | 1551-4005 1538-4101 |
| DOI: | 10.4161/cc.5.11.2803 |
| Popis: | Ovarian steroid production and subsequent local steroid-mediated signaling are critical for normal ovarian processes, including follicle growth, oocyte maturation, and ovulation. In contrast, elevated steroidogenesis and/or increased steroid signaling in the ovary can lead to profound ovarian pathology, such as polycystic ovarian syndrome, the leading cause of infertility in reproductive age women. Through the use of several in vitro and animal models, great strides have been made toward characterizing the mechanisms regulating local steroid production and action in the ovary. Examples of this progress include insights into luteinizing hormone (LH)- and growth factor-mediated signaling, steroidogenic acute regulatory protein (StAR) activation, and both genomic and nongenomic steroid-mediated signaling in somatic and germ cells, respectively. The following review will address these advances, focusing on how this rapidly expanding knowledge base can be used to better understand female reproduction, and to further improve treatments for common diseases of infertility. |
| Databáze: | OpenAIRE |
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