Adenosine and the regional differences in adipose tissue metabolism in women
| Autor: | Leila Keso, Jorma J. Ohisalo, Tuula Kiviluoto, Susanna Stoneham |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
Adenosine Endocrinology Diabetes and Metabolism media_common.quotation_subject Adipose tissue White adipose tissue Biology 03 medical and health sciences 0302 clinical medicine Endocrinology Pregnancy Internal medicine Lactation Abdomen medicine Extracellular Humans Femur Menstrual cycle 030304 developmental biology media_common 0303 health sciences General Medicine Metabolism Middle Aged Pathophysiology Menstruation medicine.anatomical_structure Adipose Tissue 030220 oncology & carcinogenesis Female medicine.drug |
| Zdroj: | Acta endocrinologica. 118(3) |
| ISSN: | 0001-5598 |
| Popis: | Adenosine content in abdominal and femoral adipose tissue in menstruating women was 0.38 ± 0.10 and 0.59 ± 0.14 nmol/g of wet weight, respectively (mean ± sem; N = 17). No difference in adenosine sensitivity was found between abdominal and femoral adipocytes. In lactating women, the adenosine content was lower in femoral than in abdominal adipose tissue (0.40 ± 0.08 and 0.57 ± 0.08 nmol/g of wet weight, respectively; N = 10). Adenosine sensitivity in femoral adipocytes was not increased during lactation. As adenosine is a locally acting insulin-like effector, these results suggest that the higher adenosine content in femoral adipose tissue in menstruating women could explain its higher lipoprotein lipase activity and tendency to accumulate fat. During lactation, the lower extracellular adenosine concentration would allow lipid mobilization preferentially from the femoral site. |
| Databáze: | OpenAIRE |
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