Acetylcholine-induced whealing in cholinergic urticaria – What does it tell us?
| Autor: | Pia Schumacher, Marcus Maurer, Sabine Altrichter, Ola Alraboni, Martin K. Church, Yiyu Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Injections Intradermal Urticaria Cholinergic Agents Wheal and flare Sweating Dermatology Controlled studies Sensitivity and Specificity Biochemistry SWEAT 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Humans In patient Cholinergic urticaria Molecular Biology Skin Skin Tests integumentary system business.industry Middle Aged medicine.disease Acetylcholine Healthy Volunteers 030104 developmental biology Case-Control Studies Anesthesia Feasibility Studies Female business medicine.drug |
| Zdroj: | Journal of Dermatological Science. 103:10-15 |
| ISSN: | 0923-1811 |
| DOI: | 10.1016/j.jdermsci.2021.05.001 |
| Popis: | Cholinergic urticaria (CholU) is characterized by the occurrence of itchy wheals induced by sweating. Intradermal injections of acetylcholine (ACh) have been proposed to help with diagnosing CholU and subgrouping of patients, but controlled studies are largely missing.To compare the rates of positive ACh test results in well characterized CholU patients and controls and to identify clinical features of CholU linked to ACh reactivity.Acetylcholine was injected intradermally into 38 CholU patients and 73 matched healthy controls. Wheal and flare skin responses were assessed after 15 and 30 min and correlated with clinical features of CholU.At 15 min after intradermal injections of ACh, wheal and flare responses were significantly more frequent in CholU patients than healthy controls, wheals: 34 % vs.15% (P = 0.028); flares: 50 % vs.18 % (P0.001). Also, wheals were 37 % and flares 172 % larger and of longer duration in CholU patients than in healthy controls (both P0.01). CholU patients with ACh-induced wheals (AChIntradermal ACh testing does not allow for the identification of CholU patients due to its low sensitivity. ACh-induced wheals, in patients with CholU, is linked to sweating and longer lasting symptoms. Intradermal ACh testing is an interesting tool for mechanistic studies in CholU. |
| Databáze: | OpenAIRE |
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