T-cell Large Granular Lymphocytic Leukemia Manifesting in Patients with HIV-1 Infection: Cases Series and Review of the Literature
| Autor: | Lubomir Sokol, Van den Bergh M, Ashley Rose, Isenalumhe L |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Lymphocytosis
Large granular lymphocytic leukemia T cell 03 medical and health sciences clonal 0302 clinical medicine Immunophenotyping hemic and lymphatic diseases medicine T-cell LGLL business.industry lcsh:RC633-647.5 leukemia Hematology lcsh:Diseases of the blood and blood-forming organs medicine.disease Lymphoma AIDS Leukemia large granular lymphocyte Infectious Diseases medicine.anatomical_structure 030220 oncology & carcinogenesis Immunology HIV-1 medicine.symptom business CD8 Monoclonal gammopathy of undetermined significance 030215 immunology |
| Zdroj: | Mediterranean Journal of Hematology and Infectious Diseases, Vol 10, Iss 1, Pp e2018036-e2018036 (2018) |
| ISSN: | 2035-3006 |
| Popis: | We report five patients with human immunodeficiency virus-1/acquired immunodeficiency syndrome (HIV-1/AIDS) who developed T-cell large granular lymphocytic proliferation (T-LGLP) or leukemia (T-LGLL). None of the patients fulfilled criteria for diagnosis of diffuse infiltrative lymphocyte syndrome (DILS) or HIV-associated CD8+ lymphocytosis syndrome at the time of diagnosis of LGL. The immunophenotype of malignant T-cells was identical in three patients with co-expression of CD3, CD8, CD57, and T-cell receptor (TCR) alpha/beta. Three out of five patients were also diagnosed with clonal disorders of B-cell origin including diffuse large B-cell lymphoma, Burkitt's lymphoma, and monoclonal gammopathy of undetermined significance (MGUS). Two patients developed cytopenias due to T-LGLL prompting initiation of therapy. Our study suggests that chronic viral infection with HIV can contribute to the evolution of T-LGLP. Clinical and laboratory characteristics of T-LGLP associated with HIV-1/AIDS resemble those of immunocompetent patients. |
| Databáze: | OpenAIRE |
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