The impact of tumor grade on survival end points and patterns of recurrence of 949 patients with early-stage endometrioid carcinoma: a single institution study
| Autor: | N. Rasool, Omar H. Gayar, Suketu Patel, Mohamed A. Elshaikh, Meredith Mahan, Daniel Schultz |
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| Rok vydání: | 2013 |
| Předmět: |
Oncology
Adult medicine.medical_specialty Michigan medicine.medical_treatment Systemic therapy Gastroenterology Tumor grade Uterine cancer Internal medicine Carcinoma medicine Humans Stage (cooking) Neoplasm Metastasis Lymph node Aged Retrospective Studies Aged 80 and over Hysterectomy business.industry Obstetrics and Gynecology Genitalia Female Middle Aged medicine.disease Endometrial Neoplasms Dissection medicine.anatomical_structure Female Neoplasm Grading Neoplasm Recurrence Local business Carcinoma Endometrioid |
| Zdroj: | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 24(1) |
| ISSN: | 1525-1438 |
| Popis: | ObjectivesThis study aimed to determine the impact of tumor grade on patterns of recurrence and survival end points in patients with endometrioid carcinoma 2009 International Federation of Gynecology and Obstetrics stages I-II.MethodsWe identified 949 patients who underwent hysterectomy between 1988 and 2011. Patients were divided into 3 groups based on tumor grade. Kaplan-Meier plots were generated for each group for recurrence-free survival (RFS), disease-specific survival (DSS), and overall survival (OS).ResultsMedian follow-up was 52 months. Median age was 60 years. All patients underwent total abdominal hysterectomy and salpingo-oophorectomy. Eighty percent of patients underwent lymph node dissection, 83% had peritoneal cytology. There were 76 (8%) patients who developed tumor recurrence. Tumor recurrence rates were significantly higher in patients with grade 3 tumors compared to grade 1 (P = 0.006). Additionally, patients with grade 3 tumors developed significantly more frequent distant metastases compared to patients with grade 1 (P = 0.002). Five-year RFS for the patients with grade 1, 2, and 3 were 95%, 82%, and 68%, respectively (P = P = P = ConclusionsInternational Federation of Gynecology and Obstetrics grade is a strong predictor of clinical survival end points in women with early-stage endometrioid carcinoma. The pattern of recurrence in patients with grade 3 tumors is mainly distant rather than locoregional. Further studies incorporating systemic therapy in the adjuvant settings in these patients are warranted. |
| Databáze: | OpenAIRE |
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