NSAID is inversely associated with asymptomatic gastric ulcer: local health examination data from the Korean National Health Insurance Corporation
| Autor: | Hyeon Geun Cho, Hee Man Kim, Si Young Song, Yu Jin Kim, Jae Hee Cho, Song Wook Chun, Kijun Han, Jin Yi Choi |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis National Health Programs Cross-sectional study Subgroup analysis digestive system Asymptomatic Gastroenterology Risk Factors Internal medicine Surveys and Questionnaires Republic of Korea medicine Odds Ratio Humans Endoscopy Digestive System Stomach Ulcer Stage (cooking) Asymptomatic Diseases Aged Aged 80 and over business.industry Anti-Inflammatory Agents Non-Steroidal Odds ratio Middle Aged Health Surveys digestive system diseases Confidence interval Cross-Sectional Studies Logistic Models Duodenal Ulcer Multivariate Analysis Female medicine.symptom business |
| Zdroj: | Scandinavian journal of gastroenterology. 48(12) |
| ISSN: | 1502-7708 |
| Popis: | BACKGROUND. Silent peptic ulcer has been considered to be associated with nonsteroidal anti-inflammatory drug (NSAID). The recent studies have reported no relationship between them. AIM. We attempted to investigate an association between asymptomatic peptic ulcer and NSAID in Korean adults. METHODS. The subjects were enrolled from participants visiting Myongji Hospital for health examination program of the Korean National Health Insurance Corporation. The questionnaires were designed to investigate individual medical information and gastroduodenal symptoms. RESULTS. From May 2005 to March 2009, 5459 participants were enrolled and 299 participants were excluded. Of 5160 participants, 3144 (60.9%) participants were asymptomatic and 424 (8.2%) participants had peptic ulcer. Among 3144 asymptomatic participants, NSAID-taking participants had the odds ratio of 1.4 [95% confidence interval (CI): 0.7-2.6, p = 0.339] for the risk of peptic ulcer. Among 424 peptic ulcer patients, 247 (58.3%) were asymptomatic. They had lower prevalence of NSAID use (4.9% vs. 14.7%). The asymptomatic gastric ulcer patients had smaller size and more frequent healing stage than the symptomatic gastric ulcer patients. In multivariable analysis of 424 peptic ulcer patients, NSAID patients had the odds ratio of 0.249 (95%CI: 0.115-0.536, p < 0.05) for asymptomatic peptic ulcer. In subgroup analysis of 284 gastric ulcer patients, NSAID-taking patients had the odds ratio of 0.263 (95% CI: 0.105-0.657, p = 0.004) for asymptomatic peptic ulcer. CONCLUSION. NSAID has an inverse association with asymptomatic patients with gastric peptic ulcer, but has no association with gastroduodenal symptoms in duodenal ulcer patients. These suggest that NSAID may be associated with gastroduodenal symptoms rather than masking symptoms, at least in gastric ulcer patients. |
| Databáze: | OpenAIRE |
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