Synthesis and evaluation of a tag-free photoactive phospho-ceramide analogue-1 (PCERA-1) probe to study immunomodulation in macrophages

Autor:	Orna Ernst, Muhammad Athamna, Michael M. Meijler, Roi Mashiach, Raju Adepu, Tsaffrir Zor, Rambabu Dandela, Rachel Gregor, Efrat Zecharia
Rok vydání:	2017
Předmět:	0301 basic medicine Lipopolysaccharides Inflammation 010402 general chemistry Ceramides 01 natural sciences Catalysis Synthetic analogue Immunomodulation 03 medical and health sciences Mice Structure-Activity Relationship Materials Chemistry medicine Macrophage Animals Dose-Response Relationship Drug Molecular Structure Chemistry Macrophages Metals and Alloys Phospho-ceramide analogue-1 General Chemistry Photochemical Processes 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials 030104 developmental biology RAW 264.7 Cells Biochemistry Molecular Probes Ceramics and Composites medicine.symptom
Zdroj:	Chemical communications (Cambridge, England). 53(27)
ISSN:	1364-548X
Popis:	Phospho-ceramide analogue-1 (PCERA-1), a synthetic analogue of ceramide-1-phosphate (C1P), has been previously shown to act as a potent modulator of macrophage activity and inflammation. We have developed an efficient synthesis of PCERA-1 from readily available starting materials, and designed and prepared derivatives of this analogue, including a photoaffinity probe to tag and identify putative proteins that bind PCERA-1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa74ada0155c14efedbbcb82fe71cdb https://pubmed.ncbi.nlm.nih.gov/28317057 Zobrazit plný text záznamu