Evaluation of precursor prostate-specific antigen isoform ratios in the detection of prostate cancer
| Autor: | V. A. Bhadkamkar, Richard J. Babaian, Stephen D. Mikolajczyk, Harry G. Rittenhouse, Herbert A. Fritsche, Yoshio Naya |
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| Rok vydání: | 2004 |
| Předmět: |
Gene isoform
PCA3 Male medicine.medical_specialty Urology Adenocarcinoma Sensitivity and Specificity Prostate cancer Prostate Internal medicine Biomarkers Tumor Medicine Humans Protein Isoforms Protein Precursors Aged Retrospective Studies Aged 80 and over Prostatectomy business.industry Free psa Prostatic Neoplasms Organ Size Middle Aged Prostate-Specific Antigen medicine.disease Prostate-specific antigen Endocrinology medicine.anatomical_structure Oncology ROC Curve Prostate gland business Total psa |
| Zdroj: | Urologic oncology. 23(1) |
| ISSN: | 1078-1439 |
| Popis: | Objective Disease-associated isoforms of the prostate-specific antigen (PSA) have recently been identified. We evaluated the efficacy of using precursor isoforms of PSA (pPSA) and their ratios for the detection of prostate cancer. Methods Serum concentrations of [−2], [−4], and [−7]pPSA, BPSA, and free PSA (fPSA) were retrospectively measured in 43 selected men. Of the 43 men, 15 had clinical T2 prostate cancer with ultrasound-estimated prostate volumes (PVs) of >50 cm3, 13 had clinical T2 prostate cancer with (PVs) 50 cm3. We calculated sum pPSA ([−2]+[−4]+[−7]pPSA). We also compared the ratios of: free/total PSA, [−2]pPSA/fPSA, [−2]pPSA/BPSA, [−2]pPSA/(fPSA-BPSA), [−2]pPSA/(fPSA-sum pPSA), and [−2]pPSA/{fPSA-(sum pPSA+BPSA)} among these three groups. Results The median [−2]pPSA/(fPSA-sum pPSA) ratio was significantly higher in men with prostate cancer with or without large PV compared with men with large PV without prostate cancer. Values for median [−2]pPSA/free PSA ratio were higher in men with prostate cancer with or without large PV compared with men with large PV, and without prostate cancer, but the differences were not statistically significant. Conclusions In this preliminary study, [−2]pPSA/(fPSA-sum pPSA) ratio was not associated with prostate gland volume but was associated with prostate cancer. This ratio may be useful in the detection of prostate cancer, particularly in men with larger glands. |
| Databáze: | OpenAIRE |
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