Clozapine-induced myocarditis after long-term treatment: case presentation and clinical perspectives
| Autor: | R von Golitschek, Alexander Schmeisser, S Malte Tugtekin, M. Willbring, Klaus Matschke, Undine E. Lang |
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| Rok vydání: | 2008 |
| Předmět: |
Olanzapine
Male medicine.medical_specialty Psychosis Dibenzothiazepines medicine.medical_treatment Quetiapine Fumarate Electroconvulsive therapy medicine Humans Pharmacology (medical) Amisulpride Intensive care medicine Clozapine Pharmacology Middle Aged medicine.disease Psychiatry and Mental health Myocarditis Schizophrenia Anesthesia Quetiapine Sulpiride Psychology medicine.drug Antipsychotic Agents |
| Zdroj: | Journal of psychopharmacology (Oxford, England). 22(5) |
| ISSN: | 0269-8811 |
| Popis: | Clozapine is the drug of choice for treatment-resistant schizophrenia. Prompted by a patient who developed reversible clozapine-induced myocarditis after long-term treatment with clozapine for several years for chronic-resistant schizophrenia, we undertook a review of the relevant literature. Concerning the myocarditis, the patient recovered rapidly by withdrawal of clozapine and with supportive management. Psychiatric stabilisation of the patient was at least possible with a combination of quetiapine (600 mg) and amisulpride (800 mg). Well-designed studies with the aim to specifically investigate treatment options after clozapine are limited and clinical possibilities are discussed in this paper. Olanzapine and combinations using non-clozapine atypical neuroleptics have partly shown improvement, whereas evidence for successful augmentation with mood stabilisers, anticonvulsants or electroconvulsive therapy in treatment-resistant schizophrenia is limited. |
| Databáze: | OpenAIRE |
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