Patterns of recurrence after radiation therapy for high-risk neuroblastoma
| Autor: | Jinhong Jung, Sang-wook Lee, Sang Min Yoon, Eun Kyung Choi, Su Ssan Kim, Young Seok Kim, Si Yeol Song, Seung Do Ahn, Ji Hwan Jo, Minji Koh, Jong Hoon Kim, Jin-Hong Park |
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| Rok vydání: | 2019 |
| Předmět: |
Neoplasm recurrence
medicine.medical_specialty Survival medicine.medical_treatment Clinical Investigations 030218 nuclear medicine & medical imaging Neuroblastoma 03 medical and health sciences 0302 clinical medicine Medicine Radiology Nuclear Medicine and imaging Progression-free survival Stage (cooking) Chemotherapy Radiotherapy business.industry Retrospective cohort study medicine.disease Primary tumor Retrospective studies Radiation therapy medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Original Article Bone marrow Radiology business |
| Zdroj: | Radiation Oncology Journal |
| ISSN: | 2234-3156 2234-1900 |
| DOI: | 10.3857/roj.2019.00353 |
| Popis: | Purpose To investigate the patterns of recurrence in patients with neuroblastoma treated with radiation therapy to the primary tumor site. Materials and methods We retrospectively analyzed patients with high-risk neuroblastoma managed with definitive treatment with radiation therapy to the primary tumor site between January 2003 and June 2017. These patients underwent three-dimensional conformal radiation therapy or intensity-modulated radiation therapy. A total of 14-36 Gy was delivered to the planning target volume, which included the primary tumor bed and the selected metastatic site. The disease stage was determined according to the International Neuroblastoma Staging System (INSS). We evaluated the recurrence pattern (i.e., local or systemic), progression-free survival, and overall survival. Results A total of 40 patients with high-risk neuroblastoma were included in this study. The median patient age was 4 years (range, 1 to 11 years). Thirty patients (75%) had INSS stage 4 neuroblastoma. At the median follow-up of 58 months, there were 6 cases of local recurrence and 10 cases of systemic recurrence. Among the 6 local failure cases, 4 relapsed adjacent to the radiation field. The other 2 relapsed in the radiation field (i.e., para-aortic and retroperitoneal areas). The main sites of distant metastasis were the bone, lymph nodes, and bone marrow. The 5-year progression-free survival was 70.9% and the 5-year overall survival was 74.3%. Conclusion Radiation therapy directed at the primary tumor site provides good local control. It seems to be adequate for disease control in patients with high-risk neuroblastoma after chemotherapy and surgical resection. |
| Databáze: | OpenAIRE |
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