A randomized study comparing the effects of a low-carbohydrate diet and a conventional diet on lipoprotein subfractions and C-reactive protein levels in patients with severe obesity
| Autor: | Nayyar Iqbal, Linda Stern, Monica Williams, Daniel J. Rader, Frederick F. Samaha, Joyce McGrory, Prakash Seshadri, Denise A. Daily, Kathryn L. Chicano, Edward J. Gracely |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Very low-density lipoprotein medicine.medical_specialty Lipoproteins Lipoproteins VLDL Severity of Illness Index Risk Factors Weight loss Internal medicine Chylomicrons Weight Loss Diabetes Mellitus Dietary Carbohydrates medicine Humans Obesity Diet Fat-Restricted Caloric Restriction Hypolipidemic Agents biology business.industry C-reactive protein Acute-phase protein General Medicine Lipoprotein(a) Middle Aged Pennsylvania medicine.disease Lipoproteins LDL C-Reactive Protein Treatment Outcome Endocrinology Body Composition biology.protein Female lipids (amino acids peptides and proteins) Metabolic syndrome medicine.symptom Lipoproteins HDL business Biomarkers Lipoprotein Chylomicron |
| Zdroj: | The American Journal of Medicine. 117:398-405 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/j.amjmed.2004.04.009 |
| Popis: | Purpose To compare the effects of a low-carbohydrate diet and a conventional (fat- and calorie-restricted) diet on lipoprotein subfractions and inflammation in severely obese subjects. Methods We compared changes in lipoprotein subfractions and C-reactive protein levels in 78 severely obese subjects, including 86% with either diabetes or metabolic syndrome, who were randomly assigned to either a low-carbohydrate or conventional diet for 6 months. Results Subjects on a low-carbohydrate diet experienced a greater decrease in large very low-density lipoprotein (VLDL) levels (difference = −0.26 mg/dL, P = 0.03) but more frequently developed detectable chylomicrons (44% vs. 22%, P = 0.04). Both diet groups experienced similar decreases in the number of low-density lipoprotein (LDL) particles (difference = −30 nmol/L, P = 0.74) and increases in large high-density lipoprotein (HDL) concentrations (difference = 0.70 mg/dL, P = 0.63). Overall, C-reactive protein levels decreased modestly in both diet groups. However, patients with a high-risk baseline level (>3 mg/dL, n=48) experienced a greater decrease in C-reactive protein levels on a low-carbohydrate diet (adjusted difference=−2.0 mg/dL, P = 0.005), independent of weight loss. Conclusion In this 6-month study involving severely obese subjects, we found an overall favorable effect of a low-carbohydrate diet on lipoprotein subfractions, and on inflammation in high-risk subjects. Both diets had similar effects on LDL and HDL subfractions. |
| Databáze: | OpenAIRE |
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