Dopamine influences attentional rate modulation in Macaque posterior parietal cortex
| Autor: | Jochem van Kempen, Mark A. Bellgrove, Alexander Thiele, Claudia Distler, Christian Brandt |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
History
Polymers and Plastics Dopamine Population Posterior parietal cortex Sensory system Cognitive neuroscience Macaque Industrial and Manufacturing Engineering Dopamine receptor D1 biology.animal Parietal Lobe medicine Animals Attention/physiology Attention Business and International Management education Neuropharmacology Parietal Lobe/physiology Neurons education.field_of_study Multidisciplinary Iontophoresis biology Dopaminergic Macaca mulatta Neurons/physiology Neuroscience medicine.drug |
| Zdroj: | van Kempen, J, Brandt, C, Distler, C, Bellgrove, M A & Thiele, A 2022, ' Dopamine influences attentional rate modulation in Macaque posterior parietal cortex. ', Scientific Reports, vol. 12, 6914 . https://doi.org/10.1038/s41598-022-10634-w |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-022-10634-w |
| Popis: | Selective attention facilitates the prioritization of task-relevant sensory inputs over those which are irrelevant. Although cognitive neuroscience has made great strides in understanding the neural substrates of attention, our understanding of its neuropharmacology is incomplete. Cholinergic and glutamatergic contributions have been demonstrated, but emerging evidence also suggests an important influence of dopamine (DA). DA has historically been investigated in the context of frontal/prefrontal function arguing that dopaminergic receptor density in the posterior/parietal cortex is sparse. However, this notion was derived from rodent data, whereas in primates DA innervation in parietal cortex matches that of many prefrontal areas. We recorded single- and multi-unit activity whilst iontophoretically administering dopaminergic agonists and antagonists to posterior parietal cortex of rhesus macaques engaged in a spatial attention task. Out of 88 neurons, 50 showed modulation of activity induced by drug administration. Dopamine inhibited firing rates across the population according to an inverted-U shaped dose-response curve. D1 receptor antagonists diminished firing rates in broad-spiking units according to a monotonically increasing function. Additionally, dopamine modulated attentional signals in broad, but not narrow-spiking cells. Finally, both drugs modulated the pupil light reflex. These data show that dopamine plays an important role in shaping neuronal responses and modulates attentional processing in macaque parietal cortex. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink