MRI-Based Apparent Diffusion Coefficient for Predicting Pathologic Response of Rectal Cancer After Neoadjuvant Therapy: Systematic Review and Meta-Analysis
| Autor: | Marcovalerio Melis, Salvatore Amodeo, Elliot Newman, Vincenzo Desiato, Alan S. Rosman, Nicole Hindman, Russell S. Berman, H. Leon Pachter |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
business.industry Colorectal cancer Rectal Neoplasms medicine.medical_treatment General Medicine medicine.disease Neoadjuvant Therapy 030218 nuclear medicine & medical imaging body regions 03 medical and health sciences 0302 clinical medicine Diffusion Magnetic Resonance Imaging Predictive Value of Tests 030220 oncology & carcinogenesis Meta-analysis medicine Effective diffusion coefficient Pathologic Response Humans Radiology Nuclear Medicine and imaging cardiovascular diseases Radiology business Neoadjuvant therapy |
| Zdroj: | AJR. American journal of roentgenology. 211(5) |
| ISSN: | 1546-3141 |
| Popis: | The purpose of this study was to assess the use of apparent diffusion coefficient (ADC) during DWI for predicting complete pathologic response of rectal cancer after neoadjuvant therapy.A systematic review of available literature was conducted to retrieve studies focused on the identification of complete pathologic response of locally advanced rectal cancer after neoadjuvant chemoradiation, through the assessment of ADC evaluated before, after, or both before and after treatment, as well as in terms of the difference between pretreatment and posttreatment ADC. Pooled mean pretreatment ADC, posttreatment ADC, and Δ-ADC (calculated as posttreatment ADC minus pretreatment ADC divided by pretreatment ADC and multiplied by 100) in complete responders versus incomplete responders were calculated. For each parameter, we also pooled sensitivity and specificity and calculated the area under the summary ROC curve.We found 10 prospective and eight retrospective studies. Overall, pathologic complete response was observed in 22.2% of patients. Pooled mean pretreatment ADC in complete responders was 0.84 × 10Use of ADC during DWI is a promising technique for assessment of results of neoadjuvant treatment of rectal cancer. |
| Databáze: | OpenAIRE |
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