Differences in Expression of Human Leukocyte Antigen Class II Subtypes and T Cell Subsets in Behçet’s Disease with Arthritis
| Autor: | S. M. Shamsul Islam, Ju-Yang Jung, Chang-Hee Suh, Bunsoon Choi, Sung-Min Lee, Hyoun-Ah Kim, Seonghyang Sohn |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Arthritis lcsh:Chemistry Arthritis Rheumatoid Behçet’s disease 0302 clinical medicine Gene Frequency T-Lymphocyte Subsets lcsh:QH301-705.5 Spectroscopy HLA-D Antigens Behcet Syndrome General Medicine Middle Aged Computer Science Applications medicine.anatomical_structure arthritis Rheumatoid arthritis Female Adult T cell HLA-DP Human leukocyte antigen Catalysis Article Inorganic Chemistry 03 medical and health sciences HLA-DQ HLA-DR medicine Humans Physical and Theoretical Chemistry Molecular Biology business.industry Organic Chemistry Genetic Variation medicine.disease 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Gene Expression Regulation inflammation Case-Control Studies Immunology business CD8 030215 immunology |
| Zdroj: | International Journal of Molecular Sciences Volume 20 Issue 20 International Journal of Molecular Sciences, Vol 20, Iss 20, p 5044 (2019) |
| ISSN: | 1422-0067 |
| Popis: | It has been reported Human Leukocyte Antigen (HLA) gene polymorphism is a risk factor for the development of Behç et&rsquo s disease (BD). In this study, the association of HLA class II subtypes HLA-DP, DQ, DR, and T cell subsets in BD patients with arthritis was evaluated. Frequencies of HLA-DP, DQ, DR positive cells, and T cell subsets in peripheral blood leukocytes (PBL) were measured by flow cytometric analysis in BD, and compared to rheumatoid arthritis as disease controls and healthy controls. Frequencies of HLA-DQ were significantly decreased in whole PBL and granulocytes of BD active patients as compared to healthy controls. In monocytes populations, proportions of HLA-DR positive cells were significantly increased in BD active patients as compared to healthy controls. Proportions of CD4+CCR7+ and CD8+CCR7+ cells were significantly higher in BD active patients than in BD inactive in whole PBL. Frequencies of CD4+CD62L- and CD8+CD62L- cells in lymphocytes were significantly decreased in active BD than those in inactive BD. There were also correlations between disease activity markers and T cell subsets. Our results revealed HLA-DP, DQ, and DR expressing cell frequencies and several T cell subsets were significantly correlated with BD arthritis symptoms. |
| Databáze: | OpenAIRE |
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