Infection free 'resisters' among household contacts of adult pulmonary tuberculosis

Autor: Vidya Mave, Padmapriyadarshini Chandrasekaran, Amol Chavan, Shri Vijay Bala Yogendra Shivakumar, Kavitha Danasekaran, Mandar Paradkar, Kannan Thiruvengadam, Aarti Kinikar, Lakshmi Murali, Sanjay Gaikwad, Luke Elizabeth Hanna, Vandana Kulkarni, Sathyamoorthy Pattabiraman, Nishi Suryavanshi, Beena Thomas, Rewa Kohli, Gomathi Narayan Sivaramakrishnan, Neeta Pradhan, Brindha Bhanu, Anju Kagal, Jonathan Golub, Neel Gandhi, Akshay Gupte, Nikhil Gupte, Soumya Swaminathan, Amita Gupta, CTRIUMPH RePORT India Study Team
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Bacterial Diseases
Pulmonology
Epidemiology
0302 clinical medicine
Endocrinology
Medicine and Health Sciences
Public and Occupational Health
030212 general & internal medicine
Child
Disease Resistance
0303 health sciences
Family Characteristics
Multidisciplinary
biology
Vaccination and Immunization
3. Good health
Actinobacteria
Infectious Diseases
symbols
Medicine
Female
Research Article
Adult
Protective immunity
medicine.medical_specialty
Tuberculosis
Adolescent
Endocrine Disorders
Science
Immunology
Tuberculin
India
Mycobacterium tuberculosis
03 medical and health sciences
symbols.namesake
Pulmonary tuberculosis
Latent Tuberculosis
Diagnostic Medicine
Internal medicine
Vaccine Development
medicine
Diabetes Mellitus
Humans
Poisson regression
Tuberculosis
Pulmonary
030304 developmental biology
Skin Tests
Bacteria
business.industry
Tuberculin Test
Organisms
Biology and Life Sciences
medicine.disease
biology.organism_classification
Tropical Diseases
bacterial infections and mycoses
Metabolic Disorders
Preventive Medicine
business
Mycobacterium Tuberculosis
Zdroj: PLoS ONE, Vol 14, Iss 7, p e0218034 (2019)
PLoS ONE
ISSN: 1932-6203
Popis: Despite substantial exposure to infectious pulmonary tuberculosis (TB) cases, some household contacts (HHC) never acquire latent TB infection (LTBI). Characterizing these "resisters" can inform who to study immunologically for the development of TB vaccines. We enrolled HHCs of culture-confirmed adult pulmonary TB in India who underwent LTBI testing using tuberculin skin test (TST) and QuantiFERON TB Gold Test-in-tube (QFT-GIT) at baseline and, if negative by both (
Databáze: OpenAIRE
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