Effect of the Inhibition of Angiotensin I Converting Enzyme in Endotoxin and Hemorrhagic Shock
| Autor: | A. Gecse, D. R. Downs, W. H. Massion, E. G. Erdös |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
chemistry.chemical_classification Time Factors Chemistry Peptide inhibitor Angiotensin-Converting Enzyme Inhibitors Blood Pressure Shock Hemorrhagic Pharmacology Angiotensin I converting enzyme Shock Septic General Biochemistry Genetics and Molecular Biology Dogs Enzyme Blood pressure Hemorrhagic shock Animals Female Oligopeptides |
| Zdroj: | Experimental Biology and Medicine. 145:948-951 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-145-37930 |
| Popis: | SummaryWe studied the role of the angiotensin I converting enzyme in shock Dogs were shocked by injection of E. coli endotoxin or by bleeding. The animals in the experiments were pretreated by iv administration of SQ 20881, the synthetic peptide inhibitor of the converting enzyme. The administration of the inhibitor blocked or attenuated the compensatory rise that followed the initial drop in systemic arterial pressure. In hypovolemic shock, as well, the inhibitor significantly delayed and decreased this compensatory rise in blood pressure. The results indicate that the enzyme has important function in shock. |
| Databáze: | OpenAIRE |
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