Interactions of non-polar and 'Click-able' nucleotides in the confines of a DNA polymerase active site
| Autor: | Wolfgang Welte, Samra Obeid, Andreas Marx, Kay Diederichs, Holger Busskamp |
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| Rok vydání: | 2012 |
| Předmět: |
Models
Molecular Molecular Sequence Data DNA-Directed DNA Polymerase Catalysis Catalytic Domain Materials Chemistry Base sequence A-DNA Nucleotide Polymerase chemistry.chemical_classification biology Base Sequence Molecular Structure Chemistry Nucleotides Metals and Alloys Rational design Active site General Chemistry Surfaces Coatings and Films Electronic Optical and Magnetic Materials Biochemistry ddc:540 Ceramics and Composites biology.protein Non polar |
| Zdroj: | Chemical communications (Cambridge, England). 48(67) |
| ISSN: | 1364-548X |
| Popis: | Modified nucleotides play a paramount role in many cutting-edge biomolecular techniques. The present structural study highlights the plasticity and flexibility of the active site of a DNA polymerase while incorporating non-polar “Click-able” nucleotide analogs and emphasizes new insights into rational design guidelines for modified nucleotides. |
| Databáze: | OpenAIRE |
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