The use of HCT and/or ACE inhibitors significantly increases the risk of non-melanotic skin cancer in the periocular region

Autor: Juliane Mehlan, Julian Ueberschaar, K. Hagenström, C. Garbe, M. S. Spitzer, V. Druchkiv, F. Schuettauf
Rok vydání: 2022
Předmět:
Zdroj: Graefe's Archive for Clinical and Experimental Ophthalmology.
ISSN: 1435-702X
0721-832X
DOI: 10.1007/s00417-022-05576-y
Popis: Background/Aims To investigate a possible association between the use of hydrochlorothiazide (HCT) and/or angiotensin-converting enzyme inhibitors (ACE inhibitors) and the occurrence of periocular non-melanoma skin cancer. Methods The files of 929 patients from the University Medical Center Hamburg-Eppendorf who were surgically treated for suspected periocular malignancy were evaluated retrospectively regarding the occurrence of non-melanoma skin cancer and concomitant medication. To be able to put the data in an overall context, we also analyzed age-matched routine data of the DAK-Gesundheit (DAK-G), a nationwide operating German health insurance company. Results Of the 929 patient records examined, who underwent surgical excision for suspected non-melanotic malignancy, non-melanocytic skin cancer could actually be determined by histology in 199 patients. In total, 176 patients (103 women, 72 men) had a basal cell carcinoma and 23 patients (16 women, 7 men) suffered from squamous cell carcinoma. The rate of intake of HCT or ACE inhibitors in our patient collective with non-melanotic skin cancer is significantly higher than in the general age-matched population (ORACE: 2.51, p p p Conclusion The rate of intake of HCT or ACE inhibitors is significantly higher in our patient collective with non-melanotic skin cancer compared to the group from the age-matched general population (DAK insured (p
Databáze: OpenAIRE
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