Diagnosis and Individualized Treatment of Secondary Central Nervous System Lymphoma: A Case Report
| Autor: | Huan Li, Qian Li, Wei Liu, Yifu Tian, Kai Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Aggressive lymphoma Case Report 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine immune system diseases ibrutinib Internal medicine hemic and lymphatic diseases medicine Bruton's tyrosine kinase Pharmacology (medical) biology business.industry secondary central nervous system lymphoma medicine.disease Pneumocystis jirovecii pneumonia diffuse large B cell lymphoma Lymphoma Regimen 030104 developmental biology Respiratory failure chemistry 030220 oncology & carcinogenesis Ibrutinib biology.protein individualized therapy Rituximab business Diffuse large B-cell lymphoma medicine.drug |
| Zdroj: | OncoTargets and therapy |
| ISSN: | 1178-6930 |
| Popis: | Non-Hodgkin lymphoma can disseminate to the central nervous system at initiation of treatment for systemic lymphoma or spread during the relapse of systematic lymphoma with CNS involvement, which is defined as secondary central nervous system lymphoma (SCNSL). The incidence of SCNSL depends on the pathological type of lymphoma and is especially high in aggressive lymphoma. SCNSL has a poor prognosis because of the lack of effective treatment regimens. This article presents a rare case of SCNSL; an individualized treatment regimen was designed according to the genetic analyses of the patient tumor and included a Bruton’s tyrosine kinase (BTK) inhibitor. After six cycles of treatment and another two cycles of rituximab, most lesions lost their metabolic activity. However, in the final stage of treatment, our patient unfortunately suffered from respiratory failure, which revealed that we should pay attention to Pneumocystis jirovecii pneumonia during ibrutinib treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |