Creation of a Curated Aquatic Toxicology Database: EnviroTox
| Autor: | Jessica L. Brill, Aude Kienzler, Mace G. Barron, Mark Bonnell, Kristin A. Connors, Ryan R. Otter, Scott E. Belanger, Dick de Zwart, Michelle R. Embry, Joshua L. Phillips, Amy Beasley, Jesse M. Krailler |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Aquatic Organisms
Databases Factual Computer science Health Toxicology and Mutagenesis Toxicological threshold of concern Ecological threshold 010501 environmental sciences computer.software_genre Ecotoxicology 01 natural sciences Risk Assessment Field (computer science) Environmental data Aquatic toxicology Set (abstract data type) Database 03 medical and health sciences Toxicity Tests Acute Environmental Chemistry De minimis Animals Hazard/Risk Assessment Aquatic toxicity Environmental toxicology Toxicity Tests Chronic 030304 developmental biology 0105 earth and related environmental sciences 0303 health sciences Information quality Information source computer Water Pollutants Chemical |
| Zdroj: | Environmental Toxicology and Chemistry |
| ISSN: | 1552-8618 0730-7268 |
| Popis: | Flexible, rapid, and predictive approaches that do not require the use of large numbers of vertebrate test animals are needed because the chemical universe remains largely untested for potential hazards. Development of robust new approach methodologies and nontesting approaches requires the use of existing information via curated, integrated data sets. The ecological threshold of toxicological concern (ecoTTC) represents one such new approach methodology that can predict a conservative de minimis toxicity value for chemicals with little or no information available. For the creation of an ecoTTC tool, a large, diverse environmental data set was developed from multiple sources, with harmonization, characterization, and information quality assessment steps to ensure that the information could be effectively organized and mined. The resulting EnviroTox database contains 91 217 aquatic toxicity records representing 1563 species and 4016 unique Chemical Abstracts Service numbers and is a robust, curated database containing high‐quality aquatic toxicity studies that are traceable to the original information source. Chemical‐specific information is also linked to each record and includes physico‐chemical information, chemical descriptors, and mode of action classifications. Toxicity data are associated with the physico‐chemical data, mode of action classifications, and curated taxonomic information for the organisms tested. The EnviroTox platform also includes 3 analysis tools: a predicted‐no‐effect concentration calculator, an ecoTTC distribution tool, and a chemical toxicity distribution tool. Although the EnviroTox database and tools were originally developed to support ecoTTC analysis and development, they have broader applicability to the field of ecological risk assessment. Environ Toxicol Chem 2019;9999:1–12. © 2019 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC. |
| Databáze: | OpenAIRE |
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