Non-Fouling Character of Poly[2-(methacryloyloxy)ethyl Phosphorylcholine]-Modified Gold Surfaces Fabricated by the ‘Grafting to’ Method: Comparison of its Protein Resistance with Poly(ethylene glycol)-Modified Gold Surfaces

Autor:	Yukio Nagasaki, Takumi Hirase, Jeppe Madsen, Keitaro Yoshimoto, Steven P. Armes
Rok vydání:	2009
Předmět:	Biofouling Materials science Polymers and Plastics Fouling Ellipsometry Phosphorylcholine Organic Chemistry Polymer chemistry PEG ratio Materials Chemistry Polymer brush Grafting Protein adsorption
Zdroj:	Macromolecular Rapid Communications. 30:2136-2140
ISSN:	1521-3927 1022-1336
DOI:	10.1002/marc.200900484
Popis:	Poly[2-(methacryloyloxy)ethyl phosphorylcholine] -modified gold surfaces, which have been newly prepared by a 'grafting to' method using a series of monosulfanyl-terminated PMPC, are characterized by protein adsorption experiments based on surface plasmon resonance spectroscopy and ellipsometry measurements. The extent of BSA adsorption on PMPC-modified surfaces was systematically reduced for thicker PMPC layers, thus the number of MPC units on the gold surface appears to be an important factor for the excellent protein resistance offered by PMPC-modified gold surfaces fabricated by the 'grafting to' method, which is sharp contrast to that of PEG tethered chains.
Databáze:	OpenAIRE
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