Quantitative sensory examination of epidural anaesthesia and analgesia in man; dose-response effect of bupivacaine
| Autor: | Jannick Brennum, Allan Horn, Pernille T. Nielsen, Lars Arendt-Nielsen, Niels H. Secher |
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| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
Pain Threshold
Adult Anesthesia Epidural Male Skin Temperature/drug effects Hot Temperature genetic structures Pain Threshold/drug effects Analgesic Pain Reaction Time/drug effects Sensory system Somatosensory system Isometric Contraction/drug effects Response effect Double-Blind Method Pain/drug therapy Isometric Contraction Physical Stimulation Reaction Time Medicine Humans Bupivacaine Hypoalgesia Dose-Response Relationship Drug business.industry Lasers Electric Stimulation Blockade Analgesia Epidural Anesthesiology and Pain Medicine Nociception Neurology Anesthesia Female Psychomotor Performance/drug effects Neurology (clinical) Bupivacaine/administration & dosage Skin Temperature business Psychomotor Performance medicine.drug |
| Zdroj: | Brennum, J, Jensen, P T, Horn, A, Arendt-Nielsen, L & Secher, N H 1994, ' Quantitative sensory examination of epidural anaesthesia and analgesia in man; dose-response effect of bupivacaine ', Pain, vol. 56, no. 3, pp. 315-26 . https://doi.org/10.1016/0304-3959(94)90170-8 |
| DOI: | 10.1016/0304-3959(94)90170-8 |
| Popis: | Time and dose-response functions of 4 concentrations of epidural bupivacaine (0.075, 0.125, 0.25, and 0.5%; 20 ml) on somatosensory and motor functions were examined in 10 healthy volunteers. Every hour for 8 h the effect of epidural bupivacaine on perception of painful and non-painful stimuli was quantified with 12 psychophysical measures. In addition knee extension strength, reaction time and skin temperature were examined. The two lowest concentrations of bupivacaine induced hypoalgesia without impairment of motor function. Epidural bupivacaine produced differential blockade of non-painful somatosensory functions in the following order: warmth perception > cold perception > perception of electrical stimuli. Epidural bupivacaine induced more pronounced hypoalgesia for short-lasting than for prolonged stimuli. A modality-related blocking order was observed for prolonged painful stimuli: heat > mechanical > electrical. It is suggested that differential blockade of somatosensory functions is caused by differences both in conduction blockade of nerve fibres and in central integration of afferent nerve impulses. |
| Databáze: | OpenAIRE |
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