Peri-interventional Behavior of the Neutrophil to Lymphocyte Ratio in Patients with Intracranial Aneurysms
| Autor: | Wei-Te Wang, Philippe Dodier, Gerhard Bavinzski, Anna Cho, Andrea Reinprecht, Thomas Czech |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Complete data Neutrophils Peri Aneurysm Ruptured Gastroenterology Prognostic score 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans In patient Lymphocytes Neutrophil to lymphocyte ratio Aged Retrospective Studies Predictive marker business.industry fungi Endovascular Procedures Routine laboratory Intracranial Aneurysm Middle Aged 030220 oncology & carcinogenesis Surgery Female Neurology (clinical) business 030217 neurology & neurosurgery After treatment |
| Zdroj: | World neurosurgery. 141 |
| ISSN: | 1878-8769 |
| Popis: | The neutrophil-to-lymphocyte ratio (NLR) has been investigated as an independent predictive marker for clinical outcomes in vascular diseases. This study aimed to investigate the peri-interventional behavior of the NLR in patients with ruptured and unruptured intracranial aneurysms (IAs).A total of 117 patients with IAs, who were treated at our department and had available complete data, were retrospectively identified during a 10-year period. Routine laboratory parameters, including the neutrophil and lymphocytes counts, were evaluated before and after treatment.The baseline NLR showed significant differences between patients with ruptured and unruptured IAs (6.3 vs. 1.8; P0.001). In patients with ruptured IAs, the baseline NLR decreased significantly during the follow-up visits, whereas in unruptured IAs, the NLR remained low. Furthermore, higher baseline NLR values could also be observed in patients with ruptured IAs and fatal outcome than in surviving patients (8.0 vs. 5.4; P = 0.220). In patients with poor functional outcome, defined as modified Rankin score ≥3, the NLR was significantly higher before treatment (P = 0.047), at day 10 (P = 0.025), and 1 month after treatment (P = 0.001).The peri-interventional NLR was significantly different between patients with ruptured and unruptured IAs. In patients with ruptured IAs, elevated baseline NLR levels were associated with poor postoperative functional outcomes and decreased postoperatively, implying the potential prognostic value of NLR in patients with IAs. |
| Databáze: | OpenAIRE |
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