Computational analysis based on audioprofiles: A new possibility for patient stratification in office-based otology
| Autor: | Oren Weininger, Thomas Lenarz, Anke Lesinski-Schiedat, Stefan R. O. Stolle, Athanasia Warnecke |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Audiogram Genotype Hearing loss Audiology Machine learning Progressive hearing loss Phenotype Article 03 medical and health sciences 0302 clinical medicine Otology medicine otorhinolaryngologic diseases Computational analysis 030223 otorhinolaryngology 030304 developmental biology Genetic testing 0303 health sciences Office based Absolute threshold of hearing medicine.diagnostic_test business.industry lcsh:Otorhinolaryngology lcsh:RF1-547 Otorhinolaryngology medicine.symptom business |
| Zdroj: | Audiology Research, Vol 9, Iss 2 (2019) Audiology Research Audiology Research; Volume 9; Issue 2; Pages: 230 |
| ISSN: | 2039-4349 2039-4330 |
| Popis: | Genetic contribution to progressive hearing loss in adults is underestimated. Established machine learning-based software could offer a rapid supportive tool to stratify patients with progressive hearing loss. A retrospective longitudinal analysis of 141 adult patients presenting with hearing loss was performed. Hearing threshold was measured at least twice 18 months or more apart. Based on the baseline audiogram, hearing thresholds and age were uploaded to AudioGene v4® (Center for Bioinformatics and Computational Biology at The University of Iowa City, IA, USA) to predict the underlying genetic cause of hearing loss and the likely progression of hearing loss. The progression of hearing loss was validated by comparison with the most recent audiogram data of the patients. The most frequently predicted loci were DFNA2B, DFNA9 and DFNA2A. The frequency of loci/genes predicted by AudioGene remains consistent when using the initial or the final audiogram of the patients. In conclusion, machine learning-based software analysis of clinical data might be a useful tool to identify patients at risk for having autosomal dominant hearing loss. With this approach, patients with suspected progressive hearing loss could be subjected to close audiological followup, genetic testing and improved patient counselling. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|