Protein, as a Regulator of Pancreatic Enzyme Secretion in the Rat
| Autor: | Barbara Ann Olds, Richard L. Lyman, Gary M. Green, Glenda Matthews |
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| Rok vydání: | 1973 |
| Předmět: |
Male
medicine.medical_specialty Protein Hydrolysates Regulator Biology General Biochemistry Genetics and Molecular Biology Catheterization Feedback Enzyme activator Pancreatic Juice Internal medicine medicine Animals Bile Chymotrypsin Secretion Pancreas Kunitz STI protease inhibitor Caseins Trypsin Rats Enzyme Activation Endocrinology Biochemistry Pancreatic juice biology.protein Trypsin Inhibitors Pancreatic enzymes medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 142:1162-1167 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-142-37199 |
| Popis: | SummaryPancreatic enzyme secretion was studied in conscious, recovered rats with bile-pancreatic juice collected directly via a cannula. When bile-pancreatic juice was collected and continuously returned to the intestine, introduction of protein evoked a marked increase in enzyme secretion, while protein hydrolysates were not effective stimulants. Diversion of bile-pancreatic juice, or introduction of soybean trypsin inhibitor, resulted in very large increases in enzyme secretion. The results support the concept of negative feedback control of pancreatic enzyme secretion, and it is proposed that protein stimulates increased pancreatic enzyme secretion by reducing feedback inhibition produced by trypsin and chymotrypsin in the intestine.The authors express their thanks to Raul Reyes for his technical assistance. |
| Databáze: | OpenAIRE |
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