Oropharyngeal microbiome of a college population following a meningococcal disease outbreak
| Autor: | Heidi M Soeters, Lorraine D. Rodriguez-Rivera, Alexander Chen, Cecilia B. Kretz, Melissa J. Whaley, Xin Wang, Adam C. Retchless |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine lcsh:Medicine Oropharynx Neisseria meningitidis medicine.disease_cause Disease Outbreaks Risk Factors lcsh:Science education.field_of_study Multidisciplinary biology Microbiota Smoking Carrier State Female Adolescent Universities 030106 microbiology Population Meningitis Meningococcal Meningococcal disease Article Microbiology Veillonella Young Adult 03 medical and health sciences Sex Factors medicine Humans Microbiome Social Behavior Students Clinical microbiology education Parvimonas micra lcsh:R Streptococcus Aggregatibacter aphrophilus medicine.disease biology.organism_classification stomatognathic diseases 030104 developmental biology Carriage Microbial Interactions lcsh:Q Metagenomics Fusobacterium nucleatum |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) |
| ISSN: | 2045-2322 |
| Popis: | Asymptomatic oropharyngeal carriage of Neisseria meningitidis peaks in adolescence and young adulthood. Following a meningococcal disease outbreak at a U.S. college, we profiled the oropharyngeal microbiomes of 158 students to identify associations between bacterial community composition and meningococcal carriage or risk factors for carriage, including male gender, smoking, and frequent social mixing. Metagenomic shotgun sequencing identified 268 bacterial taxa at the genus or species level, with Streptococcus, Veillonella, and Rothia species being most abundant. Microbiome composition showed weak associations with meningococcal carriage and risk factors for carriage. N. meningitidis abundance was positively correlated with that of Fusobacterium nucleatum, consistent with hypothesized propionic acid cross-feeding. Additional species had positive abundance correlations with N. meningitidis, including Aggregatibacter aphrophilus, Campylobacter rectus, Catonella morbi, Haemophilus haemolyticus, and Parvimonas micra. N. meningitidis abundance was negatively correlated with unidentified Veillonella species. Several of these species are commonly found in dental plaque, while N. meningitidis is primarily found in the pharynx, suggesting that ecological interactions extend throughout the oral cavity. Although risk factors for meningococcal carriage do not strongly impact most bacterial species in the oropharynx, variation in the upper respiratory tract microbiome may create conditions that are more or less favorable for N. meningitidis carriage. |
| Databáze: | OpenAIRE |
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