Autor: |
Nur Syahirah Che, Razali, Kok Wai, Lam, Nor Fadilah, Rajab, A Rahman, A Jamal, Nurul Farahana, Kamaluddin, Kok Meng, Chan |
Rok vydání: |
2022 |
Předmět: |
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DOI: |
10.21203/rs.3.rs-1509729/v2 |
Popis: |
Curcumin has demonstrated potential cytotoxicity across various cell lines despite its poor bioavailability and rapid metabolism. Therefore, our group have synthesized curcuminoid analogues with piperidone derivatives, FLDP-5 and FLDP-8 to overcome these limitations. In this study, the analogues were assessed on LN-18 human glioblastoma cells in comparison to curcumin. Results from cytotoxicity assessment showed that FLDP-5 and FLDP-8 curcuminoid analogues caused death in LN-18 cells in a concentration-dependent manner after 24-h treatment with much lower IC50 values of 2.5 µM and 4 µM respectively, which were more potent compared to curcumin with IC50 of 31 µM. Moreover, a significant increase (p p |
Databáze: |
OpenAIRE |
Externí odkaz: |
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