CC002/Unc females are mouse models of exercise-induced paradoxical fat response
| Autor: | Kunjie Hua, Vineet D. Menachery, Abbie E. Smith-Ryan, Ralph S. Baric, Martin T. Ferris, Timothy A. Bell, Daniel Pomp, Rachel C. McMullan, Fernando Pardo-Manuel de Villena |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Biometry Physiology Physical Exertion Psychological intervention Mice Inbred Strains Disease Health outcomes Bioinformatics 03 medical and health sciences Physiology (medical) Physical Conditioning Animal Genetic variation Medicine Animals Reference population Sex Characteristics business.industry Body Weight Paradoxical reaction Disease Models Animal 030104 developmental biology Adipose Tissue Body Composition Forced exercise Female business High-intensity interval training |
| DOI: | 10.17615/dxsc-c624 |
| Popis: | Exercise results in beneficial health outcomes and protects against a variety of chronic diseases. However, U.S. exercise guidelines recommend identical exercise programs for everyone, despite individual variation in responses to these programs, including paradoxical fat gain. Experimental models of exercise-induced paradoxical outcomes may enable the dissection of underlying physiological mechanisms as well as the evaluation of potential interventions. Whereas several studies have identified individual mice exhibiting paradoxical fat gain following exercise, no systematic effort has been conducted to identify and characterize models of paradoxical response. Strains from the Collaborative Cross (CC) genetic reference population were used due to its high levels of genetic variation, its reproducible nature, and the observation that the CC is a rich source of novel disease models, to assess the impact genetic background has on exercise responses. We identified the strain CC002/Unc as an exercise-induced paradoxical fat response model in a controlled voluntary exercise study across multiple ages in female mice. We also found sex and genetic differences were consistent with this pattern in a study of forced exercise programs. These results provide a novel model for studies to determine the mechanisms behind paradoxical metabolic responses to exercise, and enable development of more rational personalized exercise recommendations based on factors such as age, sex, and genetic background. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|