Cardiovascular outcome of patients with abnormal coronary vasomotion and normal coronary arteriography is worse in type 2 diabetes mellitus than in arterial hypertension: a 10 year follow-up study
| Autor: | Alain Nitenberg, Isabelle Antony, I. Pham, J. R. Attali, Paul Valensi, Denis Chemla |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Endothelium Myocardial Infarction Type 2 diabetes Coronary Angiography Constriction Angina Pectoris Predictive Value of Tests Internal medicine Diabetes mellitus medicine Humans Hypoglycemic Agents Life Tables Endothelial dysfunction Antihypertensive Agents business.industry Vascular disease Middle Aged medicine.disease Prognosis Coronary Vessels Survival Analysis Cold Temperature Stroke Vasodilation medicine.anatomical_structure Death Sudden Cardiac Diabetes Mellitus Type 2 Cardiovascular Diseases Vasoconstriction Predictive value of tests Hypertension Cardiology Female Endothelium Vascular Cardiology and Cardiovascular Medicine business Diabetic Angiopathies Artery Follow-Up Studies |
| Zdroj: | Atherosclerosis. 183(1) |
| ISSN: | 0021-9150 |
| Popis: | Diabetes and arterial hypertension are major cardiovascular risk factors. Coronary endothelial dysfunction is frequently observed in diabetic and hypertensive patients. This study was designed to compare cardiovascular outcome of hypertensive (HT) and type 2 diabetic patients (D2) with angiographically normal coronary arteries on the basis of their epicardial coronary endothelial function. Coronary reactivity assessment by cold-pressor test (CPT) using quantitative coronary angiography was achieved in 65 HT (45 males, 20 females) aged 51.9+/-7.6 years, and in 59 D2 (32 males, 27 females) aged 48.9+/-7.3 years, with angiographically normal coronary arteries and without other major coronary risk factor. Cardiovascular events (CVE) were recorded with a mean follow-up of 108+/-15 months in HT, and 113+/-10 months in D2. During CPT, in HT coronary artery dilation occurred in 10.8% of the patients, no change in 21.5%, and constriction in 67.7%. In D2, dilation occurred in 3.4% of the patients, no change in 18.6%, and constriction in 78.0%. During follow-up, in HT there were nine CVE in 6/65 patients (9.2%), all in the 6/44 (13.6%) patients with coronary artery constriction. In D2, there were 18 CVE in 16/59 patients (27.1%, P |
| Databáze: | OpenAIRE |
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