ASP2397: a novel antifungal agent produced by Acremonium persicinum MF-347833
| Autor: | Akihiko Fujie, Shigetada Furukawa, Teruhisa Masaki, Keisuke Ohsumi, Ikuko Nakamura, Michizane Hashimoto, Seiji Yoshimura, Shigehiro Takase |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Siderophore Antifungal Agents Antiparasitic medicine.drug_class Stereochemistry Chemical structure 030106 microbiology Biology Peptides Cyclic 03 medical and health sciences chemistry.chemical_compound Biosynthesis Coordination Complexes Amphotericin B Drug Discovery RNA Ribosomal 28S medicine Ferrichrome Pharmacology Malaysia Ribosomal RNA Acremonium chemistry Echinocandins medicine.drug Aluminum |
| Zdroj: | The Journal of antibiotics. 70(1) |
| ISSN: | 1881-1469 |
| Popis: | The novel antifungal agent ASP2397 (Vical's compound ID VL-2397) is produced by the fungal strain MF-347833 that was isolated from Malaysian leaf litter and is identified here as an Acremonium species based on its morphology, physiological properties and 28S ribosomal DNA sequence. Because of its potential importance for producing novel antifungal agents, we determined the taxonomic and biologic properties of MF-347833. We show here that ASP2397 is a cyclic hexapeptide that chelates aluminum ion and is therefore similar to ferrichrome, a hydroxamate siderophore. However, ASP2397 differs structurally from licensed antifungal agents such as amphotericin B, triazoles and echinocandins. To understand the relationship between chemical structure and biological function, we isolated certain ASP2397 derivatives from the culture broth, and we further chemically converted the metal-free form to other derivatives. |
| Databáze: | OpenAIRE |
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