Multiple Myeloma Complicated by Congestive Heart Failure Following First Administration of Recombinant .ALPHA.-Interferon
| Autor: | Toshiro Nagasawa, Yuichi Hasegawa, Tsukasa Abe, Yasuhiro Yoda, Toshitaka Kobayashi, Yuji Sato |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Melphalan
medicine.medical_specialty Cardiotonic Agents Vindesine Prednisolone medicine.medical_treatment Alpha interferon Gastroenterology Internal medicine Cardiovascular Disorder Antineoplastic Combined Chemotherapy Protocols Internal Medicine medicine Humans Immunologic Factors cardiovascular diseases Diuretics Intensive care medicine Adverse effect Cyclophosphamide Multiple myeloma Heart Failure business.industry Plasmapheresis General Medicine Middle Aged medicine.disease Combined Modality Therapy Recombinant Proteins Heart failure Interferon Type I Female Multiple Myeloma business medicine.drug |
| Zdroj: | Internal Medicine. 31:936-940 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.31.936 |
| Popis: | A 59-year-old female was admitted to Tsukuba University Hospital and diagnosed as IgA-lambda multiple myeloma (stage IIIA). No cardiovascular disorder with the exception of minor ischemic changes in ECG was revealed before treatment. Recombinant human alpha-interferon (IFN) at a dose of 3 million units combined with melphalan and prednisolone was administrated. Sixteen hours after the first administration of IFN, IFN was suspended by the symptoms of congestive heart failure (CHF). Treatment with diuretics and catecholamine products showed almost complete recovery from CHF in 3 weeks. An adverse reaction to IFN was strongly suspected as the cause of CHF. |
| Databáze: | OpenAIRE |
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