Ultraviolet-A induced delayed wound contraction and decreased collagen content in healing wounds and implant capsules
| Autor: | Saleh M. Shenaq, Gürhan Özcan, Hassan Chahadeh, Melvin Spira |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Contraction (grammar) Ultraviolet Rays Urology Silicones Connective tissue Rats Sprague-Dawley chemistry.chemical_compound Hydroxyproline Silicone medicine Animals Irradiation Wound Healing integumentary system business.industry Prostheses and Implants Surgery Rats medicine.anatomical_structure chemistry Implant Collagen Contracture medicine.symptom business Wound healing |
| Zdroj: | Plastic and reconstructive surgery. 92(3) |
| ISSN: | 0032-1052 |
| Popis: | Chronic exposure to ultraviolet-A radiation causes changes in the biochemistry of dermal connective tissue. To investigate its effects on wound healing, we irradiated Sprague-Dawley rats for 4 months using a black ray ultraviolet-A radiation source (560 J/cm2). Full thickness skin wounds of 2 cm in diameter were then created on the back of each animal and silicone cubes were implanted subcutaneously into the irradiated area of the back. Wound contraction in the irradiated animals (n = 28) was significantly slower than that of the controls (n = 29) (p < 0.001). Postoperatively, the hydroxyproline content of the contracted wounds and the implant capsules was assessed at 6 and 12 weeks, respectively. In the irradiated animals, it was found to be significantly less than that of the controls (p < 0.001). A delay in wound contraction and a decrease in hydroxyproline content of healing wounds and implant capsules, reflecting an alteration in collagen metabolism, are two effects of prolonged intermittent ultraviolet-A radiation pretreatment. |
| Databáze: | OpenAIRE |
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