Vitamin D and its impact on maternal-fetal outcomes in pregnancy: A critical review
| Autor: | Oormila Kovilam, Shreya Agarwal, Devendra K. Agrawal |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Article Industrial and Manufacturing Engineering vitamin D deficiency Preeclampsia 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Vitamin D and neurology Humans 030212 general & internal medicine Vitamin D Randomized Controlled Trials as Topic 030219 obstetrics & reproductive medicine business.industry Obstetrics Infant Newborn Pregnancy Outcome General Medicine Vitamin D Deficiency medicine.disease Pregnancy Complications Clinical trial Gestational diabetes Observational Studies as Topic Low birth weight Dietary Supplements Female Observational study medicine.symptom business Food Science |
| Zdroj: | Critical Reviews in Food Science and Nutrition. 58:755-769 |
| ISSN: | 1549-7852 1040-8398 |
| Popis: | The role of vitamin D beyond its classical function in calcium homeostasis has been of significant interest in recent years. There has been expanding research on the pleiotropic role of vitamin D in pregnancy and the implications of its deficiency on maternal-fetal outcomes. Several studies have associated low maternal vitamin D status to adverse outcomes in pregnancy, including preeclampsia, gestational diabetes, preterm births, low birth weight, and others. Several randomized controlled clinical trials of Vitamin D supplementation during pregnancy have also been conducted. Though some of the studies found improvement in pregnancy outcomes with vitamin D supplementation, others have not shown any association. In this article, we have critically reviewed the observational and interventional studies, published primarily within the past two years (January 2014 to February 2016) on the influence of vitamin D deficiency on pregnancy and the impact of its supplementation. The potential underlying mechanisms of vitamin D in regulating each of the outcomes have also been discussed. |
| Databáze: | OpenAIRE |
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