Accuracy of verbal fluency tests in the discrimination of mild cognitive impairment and probable Alzheimer's disease in older Spanish monolingual individuals
Autor: | César Venero, Herminia Peraita, María del Carmen Díaz-Mardomingo, Sara García-Herranz |
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Rok vydání: | 2019 |
Předmět: |
Male
medicine.medical_specialty Aging Experimental and Cognitive Psychology Disease Audiology Neuropsychological Tests Logistic regression behavioral disciplines and activities Sensitivity and Specificity 050105 experimental psychology 03 medical and health sciences Fluency 0302 clinical medicine Alzheimer Disease mental disorders medicine Dementia Verbal fluency test Humans 0501 psychology and cognitive sciences Cognitive Dysfunction Cognitive impairment Aged Verbal Behavior 05 social sciences Neuropsychology medicine.disease nervous system diseases Psychiatry and Mental health Neuropsychology and Physiological Psychology Spain Cohort Disease Progression Female Geriatrics and Gerontology Psychology human activities 030217 neurology & neurosurgery |
Zdroj: | Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition. 27(6) |
ISSN: | 1744-4128 |
Popis: | The main objetive was to analyze the accuracy of different verbal fluency tests (VFTs) in discriminating cognitively healthy subjects from individuals with mild cognitive impairment (MCI) and probable Alzheimer's disease (AD) in a cohort of older Spanish speaking adults. As a result, we aimed to identify the VFT that best predicts conversion from MCI to probable AD. 287 subjects: 170 controls (HC), 90 stable MCI and 27 patients with MCI that evolved into probable AD (MCI-AD) were assessed with a neuropsychological battery test and five VFTs. The animal fluency test produced the best differentiation of HC from MCI (p < .001), of HC from MCI-AD (p < .001) and of MCI from MCI-AD converters (p < .001), with sensitivities 98.8%, 98.8% and 75.6%, respectively. Logistic regression showed that the animal fluency test (p < 0.001) appears to be the most useful and neuropsychological VFT to predict conversion to probable dementia. |
Databáze: | OpenAIRE |
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