An immunologic study of psoriasis
| Autor: | Samia Ammar, Shadia Mabrouk, Mona El Okby, Aly Abdel Fattah, Mohamed Ghozzi |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Male Adolescent Fluorescent Antibody Technique Dermatology Immunofluorescence Pathology and Forensic Medicine Pathogenesis Psoriasis Stratum corneum Medicine Humans In patient integumentary system biology medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Immunoglobulin A medicine.anatomical_structure Immunoglobulin G Immunology Humoral immunity Skin biopsy biology.protein Female Antibody business |
| Zdroj: | The American Journal of dermatopathology. 8(4) |
| ISSN: | 0193-1091 |
| Popis: | Thirty-five patients with psoriasis and 18 normal controls were studied in order to assess the role of humoral immunity in psoriasis. Direct immunofluorescent study of skin biopsy specimens taken from the lesions revealed deposits of immunoglobulins (IgA, IgG, IgM) and complement components (Clq, C3), mainly in the stratum corneum. Deposits were also found in Munro's microabscesses, spongiform pustules of Kogoj, upper layers of the stratum malpighii, dermal blood vessels, and cells of the dermal inflammatory infiltrate. Uninvolved skin of the patients and normal controls revealed negative fluorescent results. There was a significant increase in the mean levels of IgA and IgG in patients with psoriasis, whereas IgM was within the normal range. The present study showed humoral abnormalities in psoriasis that may be involved in its pathogenesis. |
| Databáze: | OpenAIRE |
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