Albumin and calcium reference interval using healthy individuals and a data-mining approach
| Autor: | J Osborne, A Luvai, Andrew M. Day, Katharine Hayden, J West, Deepa Narayanan, Nuthar Jassam, N El-Farhan, Julian H. Barth, Rebecca J. Dearman, S Zouwail, D Turnock, S Willett, Graham R. Lee, Jinny Jeffery, K Earp |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 030213 general clinical medicine Adolescent Calibration (statistics) Clinical Biochemistry Metrological traceability Interval (mathematics) computer.software_genre Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Reference Values Data Mining Humans Medicine Serum Albumin Aged business.industry General Medicine Middle Aged United Kingdom Reference intervals 030220 oncology & carcinogenesis Healthy individuals Calcium Female Data mining business computer |
| Zdroj: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 57:373-381 |
| ISSN: | 1758-1001 0004-5632 |
| DOI: | 10.1177/0004563220944204 |
| Popis: | BackgroundHarmonization of reference intervals for analytes that have a sound calibration and metrological traceability is a widely recommended practice. The UK Pathology Harmony has recently harmonized reference intervals for calcium and albumin. In this study, we have determined the reference intervals for calcium and albumin on the UK’s most commonly used analytical platforms.MethodA prospective reference population of healthy individuals was recruited according to the IFCC CRIDL criteria. A second indirect population was collected from 14 primary care setting and measured in laboratories using various analytical platforms and methods (Roche, Abbott, Beckman and Siemens analytical platforms).ResultsIn total, 299 subjects were recruited; the central 95th centile values for calcium for three out of four analytical platforms were in a close agreement with UK Pathology Harmony reference intervals of 2.2–2.6 mmol/L. Reference intervals of BCG methods from both cohorts and irrespective of analytical platforms were higher for both lower and upper reference limits than those for BCP. In comparison, the indirect study showed an age-related variation. The younger population reference intervals varied by up to 5.7% at the lower reference limit and up to 12% at the upper reference limit compared with Pathology Harmony reference intervals, and the older population showed a variation of up to 14% at both limits.ConclusionWhile calcium reference intervals can be a subject for harmonization, albumin reference intervals studied showed large variation which is unsupportive of embracing a common reference interval for albumin. |
| Databáze: | OpenAIRE |
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