Electrolyzed Oxidizing Water Modulates the Immune Response in BALB/c Mice Experimentally Infected with Trypanosoma cruzi
| Autor: | Sergio Hernández-García, Lidia Baylón-Pacheco, Alberto Aranda-Fraustro, Olga L Pérez-Reyes, Juan José Cabrera-Mata, José Luis Rosales-Encina, Minerva Arce-Fonseca, Olivia Rodríguez-Morales, Silvia C Carrillo-Sánchez, Rodolfo A Gutiérrez-Ocejo |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Chagas disease General physical condition Trypanosoma cruzi lcsh:Medicine BALB/c murine model Immune system parasitic diseases Immunology and Allergy Medicine Parasite hosting Molecular Biology therapy General Immunology and Microbiology biology business.industry lcsh:R immunomodulator biology.organism_classification medicine.disease electrolyzed oxidizing water Infectious Diseases Benznidazole Immunology General health prophylaxis business medicine.drug |
| Zdroj: | Pathogens, Vol 9, Iss 974, p 974 (2020) Pathogens Volume 9 Issue 11 |
| ISSN: | 2076-0817 |
| Popis: | Chagas disease is a major public health problem in Latin America. The mixed Th1/Th2 immune response is required against Trypanosoma cruzi. Electrolyzed oxidizing water (EOW) has been shown to have germicidal efficacy. The objective of this study was to evaluate the EOW effectiveness in T. cruzi-infected BALB/c mice clinically, immunologically, and histologically. The severity of the infection was assessed by parasitaemia, general health condition, mortality, mega syndromes, and histological lesions. IgG, TNF-alpha, IFN-gamma, and IL-1 beta levels were quantified. The EOW administration showed a beneficial effect on parasitaemia, general physical condition, and mortality. High levels of IgG1 at 50 days postinfection were observed. Prophylactic EOW treatment was able to induce a predominantly TH1 immune response based on an IgG2a levels increase at the late acute phase, and a 10-fold increase of INF-gamma in whole acute phase. EOW was able to control the acute phase infection as effectively as benznidazole. Splenomegaly was caused by EOW treatment and lymphadenopathy was stimulated by T. cruzi infection in all groups. Severe tissue damage was not prevented by EOW treatments. Moderate efficacy may be due to immunomodulatory properties and not to a direct toxic effect on the parasite. |
| Databáze: | OpenAIRE |
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