Coexistence of chronic neutrophilic leukemia with multiple myeloma
| Autor: | Melih Aktan, Reyhan Diz Küçükkaya, Günçağ Dinçol, Mehmet Agan, Oner Dogan, Meliha Nalcaci, Koray Dinçol |
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| Rok vydání: | 2002 |
| Předmět: |
Blood Platelets
Male Cancer Research Paraproteinemia Chronic neutrophilic leukemia Hepatosplenomegaly Philadelphia chromosome Leukemia Myelomonocytic Acute Immunoglobulin kappa-Chains Fatal Outcome hemic and lymphatic diseases medicine Humans Multiple myeloma Leukemia Neutrophilic Chronic Aged business.industry Hematology medicine.disease Leukemia Oncology Immunoglobulin G Döhle bodies Immunology Acute myelomonocytic leukemia medicine.symptom business Multiple Myeloma |
| Zdroj: | Leukemialymphoma. 43(3) |
| ISSN: | 1042-8194 |
| Popis: | A case report of simultaneous presentation of chronic neutrophilic leukemia and multiple myeloma (IgG kappa) in a 71-year-old male is described. The patient showed mature neutrophilic leukocytosis, hepatosplenomegaly, high neutrophil alkaline phosphatase score, hyperuricemia, neutrophils with toxic granulation and Dohle bodies, absence of Philadelphia chromosome and of the bcr-abl fusion gene. Moreover, a monoclonal IgG kappa paraproteinemia (36.93 g l(-1)) was detected. Bence-Jones proteinuria was 3.84 g l(-1). The bone marrow was grossly hypercellular with marked myeloid hyperplasia and aggregates of plasma cells. The patient died of severe bronchopneumonia after the transformation of chronic neutrophilic leukemia to acute myelomonocytic leukemia, 1.5 years following diagnosis. |
| Databáze: | OpenAIRE |
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