Glycoside in schizophrenic patients sera affects behavior of mouse forced swimming
| Autor: | Junya Sugawara, Toshihiro Sugiyama, Yutaka Masuda, Shun Ohnuma |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Dose dependence Biology Pharmacology General Biochemistry Genetics and Molecular Biology Mice Dopamine receptor D1 Dopamine medicine Animals Humans Glycosides Threonine Swimming Forced swimming chemistry.chemical_classification Behavior Animal Receptors Dopamine D1 Antagonist Glycoside General Medicine chemistry Case-Control Studies Schizophrenia Female Schizophrenic Psychology human activities medicine.drug |
| Zdroj: | The Tohoku journal of experimental medicine. 194(4) |
| ISSN: | 0040-8727 |
| Popis: | We found a glycoside in sera of schizophrenic patients. This glycoside increased climbing of mouse forced swimming and the climbing was decreased by dopamine D1 receptor antagonist SCH-23390 with a dose dependent manner. This glycoside had much reactivity of GalNAc alpha1-3GalNAc, but not that of polymannoses nor that of Gal beta1-3GlcNAc alpha1-serine or threonine. This strongly suggests that the glycoside is an isolated O-glycoside, but not N-glycoside nor O-glycoside having core 1 or 2. The present findings suggest that schizophrenic patients have the special glycoside affecting the D1 receptor activity in their serum. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|