Prevalence of Antiretroviral Drug Resistance in Patients Who Are Not Responding to Protease Inhibitor-Based Treatment: Results From the First National Survey in South Africa
| Autor: | William B. MacLeod, Maria A. Papathanasopoulos, Dominique Goedhals, Kim Steegen, Wendy S. Stevens, C van Vuuren, Sergio Carmona, M. Bronze, Ian Sanne, G. van Zyl |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Adolescent Mutation Missense Etravirine Gene Products pol Antiretroviral drug HIV Infections Drug resistance Treatment results 03 medical and health sciences South Africa Young Adult 0302 clinical medicine Internal medicine Drug Resistance Viral medicine Prevalence Immunology and Allergy Humans Protease inhibitor (pharmacology) In patient 030212 general & internal medicine Treatment Failure Darunavir Aged business.industry HIV Protease Inhibitors Sequence Analysis DNA Middle Aged 030112 virology Virology Infectious Diseases Cross-Sectional Studies Anti-Retroviral Agents HIV-1 Ritonavir business medicine.drug |
| Zdroj: | The Journal of infectious diseases. 214(12) |
| ISSN: | 1537-6613 |
| Popis: | Limited data exist on human immunodeficiency virus type 1 (HIV-1) resistance in patients who are not responding to protease inhibitor (PI)-based regimens in resource-limited settings. This study assessed resistance profiles in adults across South Africa who were not responding to PI-based regimens. pol sequencing was undertaken and submitted to the Stanford HIV Drug Resistance Database. At least 1 major PI mutation was detected in 16.4% of 350 participants. A total of 53.4% showed intermediate resistance to darunavir/ritonavir, whereas high-level resistance was not observed. Only 5.2% and 32.8% of participants showed high-level and intermediate resistance to etravirine, respectively. Although the prevalence of major PI mutations was within previously reported ranges, most patients will likely experience virological suppression during receipt of currently available South African third-line regimens. |
| Databáze: | OpenAIRE |
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