TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines
| Autor: | Estuardo Aguilar-Cordova, Christine H. Herrmann, Andrew P. Rice, Moses O. Gold, Xinzhen Yang, Dorothy E. Lewis, Derek N.G. Tang |
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| Rok vydání: | 1997 |
| Předmět: |
Cyclin T1
Cellular differentiation RNA polymerase II HIV Infections Biology Protein Serine-Threonine Kinases Lymphocyte Activation Peripheral blood mononuclear cell Monocytes Cyclin-dependent kinase Humans Positive Transcriptional Elongation Factor B Lymphocytes Kinase activity Cyclin Multidisciplinary Kinase Cell Differentiation Biological Sciences Molecular biology Cyclin-Dependent Kinases Enzyme Induction Gene Products tat biology.protein HIV-1 tat Gene Products Human Immunodeficiency Virus |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 94(23) |
| ISSN: | 0027-8424 |
| Popis: | We have previously identified a cellular protein kinase activity termed TAK that specifically associates with the HIV types 1 and 2 Tat proteins. TAK hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase IIin vitroin a manner believed to activate transcription [Herrmann, C. H. & Rice, A. P. (1995)J. Virol. 69, 1612–1620]. We show here that the catalytic subunit of TAK is a known human kinase previously named PITALRE, which is a member of the cyclin-dependent family of proteins. We also show that TAK activity is elevated upon activation of peripheral blood mononuclear cells and peripheral blood lymphocytes and upon differentiation of U1 and U937 promonocytic cell lines to macrophages. Therefore, in HIV-infected individuals TAK may be induced in T cells following activation and in macrophages following differentiation, thus contributing to high levels of viral transcription and the escape from latency of transcriptionally silent proviruses. |
| Databáze: | OpenAIRE |
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