Time series analysis on association between ambient air pollutants and orofacial clefts during pregnancy in Lanzhou, China

Autor:	Yanyan Liu, Li Zhou, Wenling Zhang, Yanjun Yang, Yan Yang, Li Pan, Yupei Ba, Ruijuan Wang, Yanbei Huo, Xiaoyu Ren, Yana Bai, Ning Cheng
Rok vydání:	2021
Předmět:	Air Pollutants China Time Factors Health Toxicology and Mutagenesis Cleft Lip Infant General Medicine Pollution Cleft Palate Pregnancy Air Pollution Environmental Chemistry Humans Sulfur Dioxide Environmental Pollutants Female Particulate Matter
Zdroj:	Environmental science and pollution research international. 29(48)
ISSN:	1614-7499
Popis:	Current studies on air pollutant exposure during pregnancy and orofacial clefts (OFCs) have inconsistent results, and few studies have investigated refined susceptible windows for OFCs. We aim to estimate association between air pollution and OFCs during the first trimester of pregnancy and identify specific susceptible windows. Birth data was obtained from Birth Defects Surveillance Network in Lanzhou from 2014 to 2019. Air pollution data and temperature data were obtained from ambient air monitoring stations and China Meteorological Data Network, respectively. A distribution lag nonlinear model (DLNM) was applied to estimate weekly-exposure-lag-response association between air pollutant levels and OFCs. The study included 320,787 perinatal infants from 2014 to 2019, of which 685 (2.14‰) were OFCs. The results demonstrated that exposure of pregnant women to aerodynamic diameter ≤ 10 μm (PM
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7c2b48846c7b6435a5895f39cf1708 https://pubmed.ncbi.nlm.nih.gov/35618997 Zobrazit plný text záznamu Full text from SpringerLink