Monocular deprivation provokes alteration of the neuronal cytoskeleton in developing cat lateral geniculate nucleus
| Autor: | Joanna E. Slusar, Kevin R. Duffy |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Neurofilament
Physiology Presynaptic Terminals Biology Lateral geniculate nucleus Axon terminal Neurofilament Proteins Vision Monocular medicine Animals Sensory deprivation Cytoskeleton Neurons Neuronal Plasticity Geniculate Bodies Dendrites Sensory Systems Monocular deprivation medicine.anatomical_structure Animals Newborn Cats Soma sense organs Neuron Sensory Deprivation Monocular vision Neuroscience |
| Zdroj: | Visual Neuroscience. 26:319-328 |
| ISSN: | 1469-8714 0952-5238 |
| DOI: | 10.1017/s0952523809090130 |
| Popis: | Monocular deprivation early in development produces considerable change in the organization of connections within the central mammalian visual system. In the dorsal lateral geniculate nucleus, the soma, dendrites, and axon terminal fields of deprived cells become considerably smaller than nondeprived counterparts. We have examined the possibility that subcellular events enabling structural modification of deprived neurons include modification of proteins comprising the cytoskeleton. We examined the integrity of the cytoskeleton by measuring the response of a subset of its proteins to varying durations of monocular deprivation. Loss of all three neurofilament subunits (light, medium, and heavy) within deprived layers was observed to parallel changes in neuron gross structure. Monocular deprivation initiated beyond early life produced neither a change in structure nor a loss of neurofilament labeling. |
| Databáze: | OpenAIRE |
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