Association Between Residential Greenness and Cardiovascular Disease Risk

Autor: Sanjay Srivastava, Sathya Krishnasamy, Shesh N. Rai, James McCracken, Rachel J. Keith, Natasha DeJarnett, Gilbert C. Liu, Pawel Lorkiewicz, Ray Yeager, Aruni Bhatnagar, Jordan Finch, Zhengzhi Xie, Daniel W. Riggs, Nagma Zafar, Daniel J. Conklin, Andrew P. DeFilippis, David J. Tollerud, Timothy E. O'Toole, Jeffrey S. Wilson
Rok vydání: 2018
Předmět:
Adult
Male
Sympathetic Nervous System
Epinephrine
cardiovascular disease risk factors
greenness
Epidemiology
normalized difference vegetation index
Kentucky
010501 environmental sciences
Risk Assessment
01 natural sciences
Normalized Difference Vegetation Index
03 medical and health sciences
0302 clinical medicine
Residence Characteristics
Risk Factors
Cardiovascular Disease
Environmental health
Background exposure
Mechanisms
Humans
oxidative stress
Medicine
030212 general & internal medicine
Built Environment
Original Research
endothelial progenitor cells
0105 earth and related environmental sciences
F2-Isoprostanes
business.industry
Urbanization
Middle Aged
Plants
Protective Factors
Green vegetation
3. Good health
Cross-Sectional Studies
Cardiovascular Diseases
catecholamine
Disease risk
Female
Angiogenesis
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Vegetation (pathology)
environment
Biomarkers
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
ISSN: 2047-9980
Popis: Background Exposure to green vegetation has been linked to positive health, but the pathophysiological processes affected by exposure to vegetation remain unclear. To study the relationship between greenness and cardiovascular disease, we examined the association between residential greenness and biomarkers of cardiovascular injury and disease risk in susceptible individuals. Methods and Results In this cross‐sectional study of 408 individuals recruited from a preventive cardiology clinic, we measured biomarkers of cardiovascular injury and risk in participant blood and urine. We estimated greenness from satellite‐derived normalized difference vegetation index ( NDVI ) in zones with radii of 250 m and 1 km surrounding the participants’ residences. We used generalized estimating equations to examine associations between greenness and cardiovascular disease biomarkers. We adjusted for residential clustering, demographic, clinical, and environmental variables. In fully adjusted models, contemporaneous NDVI within 250 m of participant residence was inversely associated with urinary levels of epinephrine (−6.9%; 95% confidence interval, −11.5, −2.0/0.1 NDVI ) and F2‐isoprostane (−9.0%; 95% confidence interval, −15.1, −2.5/0.1 NDVI ). We found stronger associations between NDVI and urinary epinephrine in women, those not on β‐blockers, and those who had not previously experienced a myocardial infarction. Of the 15 subtypes of circulating angiogenic cells examined, 11 were inversely associated (8.0–15.6% decrease/0.1 NDVI ), whereas 2 were positively associated (37.6–45.8% increase/0.1 NDVI ) with contemporaneous NDVI . Conclusions Independent of age, sex, race, smoking status, neighborhood deprivation, statin use, and roadway exposure, residential greenness is associated with lower levels of sympathetic activation, reduced oxidative stress, and higher angiogenic capacity.
Databáze: OpenAIRE
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