Catastrophic Intracerebral Hemorrhage in a Young Infant With Wilms Tumor
| Autor: | Ronald van Toorn, Glynn Wessels, Christina Stefan |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Physical examination Sensitivity and Specificity Wilms Tumor Fatal Outcome medicine Humans Cancer staging Cause of death Intracerebral hemorrhage medicine.diagnostic_test business.industry Vascular malformation Infant Magnetic resonance imaging Wilms' tumor Hematology medicine.disease Combined Modality Therapy Kidney Neoplasms Oncology Pediatrics Perinatology and Child Health Etiology Radiology Tomography X-Ray Computed business Intracranial Hemorrhages |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 29:298-300 |
| ISSN: | 1077-4114 |
| DOI: | 10.1097/mph.0b013e3180587e7a |
| Popis: | We present a 7-month-old male infant with stage I Wilms tumor who unexpectedly died from a catastrophic intracerebral hemorrhage, 4 months after completion of chemotherapy and complete surgical resection of the tumor. The precise etiology underlying the fatal event remains unclear as postmortem was refused, but we postulate spontaneous hemorrhage from an underlying cerebral vascular malformation as the most likely cause, which led to the child's unfortunate demise. Although extremely rare, cerebral vascular anomalies have previously been reported in children with Wilms tumor. The coexistence of the 2 uncommon disorders may be related to their congenital origin. Wilms tumor diagnosed in very young infants have clinical and morphologic attributes that do not pertain in older children and the risk of associated congenital anomalies is also much higher among those discovered in the first year of life. This raises the question whether routine magnetic resonance imaging should not be performed in infants less than a year with Wilms tumor, as part of the initial evaluation, to exclude cerebral metastases and underlying vascular malformations. |
| Databáze: | OpenAIRE |
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