DSGOST inhibits tumor growth by blocking VEGF/VEGFR2-activated angiogenesis
| Autor: | Kang Min Lee, Kangwook Lee, Seong-Gyu Ko, Min Kyoung Kim, Hyeong Sim Choi, Sung-Gook Cho, Yong Cheol Shin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Vascular Endothelial Growth Factor A tumor Angiogenesis VEGF receptors Mice Nude Angiogenesis Inhibitors 03 medical and health sciences angiogenesis 0302 clinical medicine In vivo Pancreatic tumor Cell Movement Cell Line Tumor Human Umbilical Vein Endothelial Cells Medicine Animals Humans Viability assay Cells Cultured Mice Inbred BALB C Traditional medicine biology Neovascularization Pathologic business.industry NF-kappa B Cancer medicine.disease VEGF Vascular Endothelial Growth Factor Receptor-2 Xenograft Model Antitumor Assays In vitro Tumor Burden Pancreatic Neoplasms 030104 developmental biology medicine.anatomical_structure DSGOST Oncology 030220 oncology & carcinogenesis herbal medicine Cancer research biology.protein business Blood vessel Research Paper Drugs Chinese Herbal Signal Transduction |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | Tumor growth requires a process called angiogenesis, a new blood vessel formation from pre-existing vessels, as newly formed vessels provide tumor cells with oxygen and nutrition. Danggui-Sayuk-Ga-Osuyu-Saenggang-Tang (DSGOST), one of traditional Chinese medicines, has been widely used in treatment of vessel diseases including Raynaud's syndrome in Northeast Asian countries including China, Japan and Korea. Therefore, we hypothesized that DSGOST might inhibit tumor growth by targeting newly formed vessels on the basis of its historical prescription. Here, we demonstrate that DSGOST inhibits tumor growth by inhibiting VEGF-induced angiogenesis. DSGOST inhibited VEGF-induced angiogenic abilities of endothelial cells in vitro and in vivo, which resulted from its inhibition of VEGF/VEGFR2 interaction. Furthermore, DSGOST attenuated pancreatic tumor growth in vivo by reducing angiogenic vessel numbers, while not affecting pancreatic tumor cell viability. Thus, our data conclude that DSGOST inhibits VEGF-induced tumor angiogenesis, suggesting a new indication for DSGOST in treatment of cancer. |
| Databáze: | OpenAIRE |
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